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S-adenosylhomocysteine is then cleaved by adenosylhomocyteinase (also called S-adenosylhomocysteine hydrolase) to yield homocysteine and adenosine

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This explanation is no doubt parsimonious, but difficulties arise in trying to reconcile hyperhomocysteinemia with GSH levels: Hcy is directly upstream of cysteine, therefore vitamin B 12 deficiency ought to boost GSH synthesis

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